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Drug Metabolism Handbook: Concepts and Applications (2009)
Drug Metabolism Handbook: Concepts and Applications
Author: Ala F. Nassar
ISBN: 978-0-470-11803-0
Pages: 1041 pages
Publisher: Wiley
Published: February 2009
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![]() A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge tools and techniques, this book serves as a valuable reference tool for bench scientists, medical students, and students of general health sciences.
Table of Contents:
Preface.
1. Introduction and historical perspective (Roberta King).
2. Factors affecting drug metabolism (Roberta King).3. Function of metabolism (biotransformation) (Roberta King).
4. In vivo metabolite kinetics (Zheng Yang).
5. Pharmacogenomics and pharmacogenetics (Lilian Yengi).
6. Drug transporters (Louis Leung and Aram Oganesian).
7. High throughput in drug metabolism (Melvin Reichman).
8. LC-MS interpretation of soft ionization (Thomas R. Sharp).
9. Novel approach to performing metabolite elucidation: One key to success in drug metabolism (Ala Nassar).
10. Structural modification of drug candidates: how useful are they in improving metabolic stability of new drugs? (Ala Nassar).
11. Structural modification of drug candidates: how useful are they in improving PK properties of new drugs (Ala Nassar).
12. Structural modification of drug candidates: how useful are they in reducing toxicity of new drugs (Ala Nassar).
13. Genotoxicity screening using biocatalyst/DNA films and cap LC-MS/MS (James.Rusling).
14. Inhibition15. Evaluating and Predicting Human Cytochrome P450 Enzyme Induction (Michael W Sinz and Sean Kim.
16. An Introduction to Metabolic Reaction-Phenotyping (Carl D Davis and David Rodrigues).
17. Nuclear hormone receptors in drug metabolism and drug-drug interactionsinclude NR activation (Wen Xie and Hongbing wang).
18. P450 Mechanism Based Inhibition and Mass spec techniques for apo protein adduction (Larry Wienkers).
19. Clinical drug-drug interactions (Sujal V. Deshmukh).
20. Pharmaceutical Excipients in Drug-Drug Interaction.
21. Role of metabolism in drug toxicity (Umesh Hanumegowda and Carl D Davis).
22. Allergic Reactions to Drugs (Mark Grillo).
23. Chemical Mechanisms in Toxicology (Mark Grillo).
24. Mechanisms of Reproductive Toxicity (Patricia Hoyer and Aileen Keating).
25. Introduction to Toxicogenomics (Chris Bradfield and Aaron Vollrath).
26. Mechanisms of Kidney Toxicity (Larry Lash.27. Preclinical requirement/ Clinical requirement/ Marketing (Mark N Milton). |
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